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Article

Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos

3 Aug 2012

Abstract excerpt

The lymphatic vasculature preserves tissue fluid balance by absorbing fluid and macromolecules and transporting them to the blood vessels for circulation. The stepwise process leading to the formation of the mammalian lymphatic vasculature starts by the expression of the gene Prox1 in a subpopulation of blood endothelial cells (BECs) on the cardinal vein (CV) at approximately E9.5. These Prox1-expressing...

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PMID: 22859612
DOI: 10.1182/blood-2012-05-428607

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