Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity.

Genes & development - 1 Dec 2008

Johnson Nicole C, Dillard Miriam E, Baluk Peter, McDonald Donald M, Harvey Natasha L, Frase Sharon L, Oliver Guillermo

Abstract excerpt

The activity of the homeobox gene Prox1 is necessary and sufficient for venous blood endothelial cells (BECs) to acquire a lymphatic endothelial cell (LEC) fate. We determined that the differentiated LEC phenotype is a plastic, reprogrammable condition that depends on constant Prox1 activity for its maintenance. We show that conditional down-regulation of Prox1 during embryonic, postnatal, or adult stages is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Dedifferentiation
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Endothelial Cells

Share to Gene Expression Regulation, Developmental

Share to Homeodomain Proteins

Share to RNA, Small Interfering

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19056883
DOI: 10.1101/gad.1727208
PMCID: PMC2600759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity.PMID 19056883Read ↗

Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate.Semantic proximity Read ↗

Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor.Semantic proximity Read ↗

Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signatureSemantic proximity Read ↗

Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish developmentSemantic proximity Read ↗

An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype.Semantic proximity Read ↗

Endothelial cell plasticity: how to become and remain a lymphatic endothelial cellSemantic proximity Read ↗

Lymphatic Endothelial Cell Plasticity in Development and DiseaseSemantic proximity Read ↗

Prox1, master regulator of the lymphatic vasculature phenotype.Semantic proximity Read ↗

Direct specification of lymphatic endothelium from mesenchymal progenitorsSemantic proximity Read ↗

Divergence of zebrafish and mouse lymphatic cell fate specification pathways.Semantic proximity Read ↗

Epigenetic priming by Dot1l in lymphatic endothelial progenitors ensures normal lymphatic development and functionSemantic proximity Read ↗

Paraxial Mesoderm Is the Major Source of Lymphatic EndotheliumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.