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Article

Expression of different mutant p53 transgenes in neuroblastoma cells leads to different cellular responses to genotoxic agents.

Experimental cell research - 15 Apr 2002

Gangopadhyay Suman, Jalali Farid, Reda Danny, Peacock Jim, Bristow Robert G, Benchimol Samuel

Abstract excerpt

The involvement of p53 as a determinant of chemosensitivity or radiosensitivity is not well understood and is complicated by numerous contradictory reports. Here we have addressed this issue using a series of isogenic clones derived from two neuroblastoma cell lines that express wild-type p53 genes, Nub7 and IMR32. Two different mutant p53 transgenes were used in an attempt to disrupt p53 function in the clones....

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Source

Identifiers

PMID: 11925110
DOI: 10.1006/excr.2002.5493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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