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Article

Mechanisms of different response to ionizing irradiation in isogenic head and neck cancer cell lines.

Radiation oncology (London, England) - 27 Nov 2019

Todorovic Vesna, Prevc Ajda, Zakelj Martina Niksic, Savarin Monika, Brozic Andreja, Groselj Blaz, Strojan Primoz, Cemazar Maja, Sersa Gregor

Abstract excerpt

BACKGROUND: Treatment options for recurrent head and neck tumours in the previously irradiated area are limited, including re-irradiation due to radioresistance of the recurrent tumour and previous dose received by surrounding normal tissues. As an in vitro model to study radioresistance mechanisms, isogenic cells with different radiosensitivity can be used. However, they are not readily available. Therefore, our...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31775835
DOI: 10.1186/s13014-019-1418-6
PMCID: PMC6882348

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