Article
Androgen receptor mutations identified in prostate cancer and androgen insensitivity syndrome display aberrant ART-27 coactivator function.
Molecular endocrinology (Baltimore, Md.) - 1 Sept 2005
Li Wenhui, Cavasotto Claudio N, Cardozo Timothy, Ha Susan, Dang Thoa, Taneja Samir S, Logan Susan K, Garabedian Michael J
Abstract excerpt
The transcriptional activity of the androgen receptor (AR) is modulated by interactions with coregulatory molecules. It has been proposed that aberrant interactions between AR and its coregulators may contribute to diseases related to AR activity, such as prostate cancer and androgen insensitivity syndrome (AIS); however, evidence linking abnormal receptor-cofactor interactions to disease is scant. ART-27 is a...
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