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Article

Repression of virulence genes by phosphorylation‐dependent oligomerization ofCsrR at target promoters in <i>S. pyogenes</i>

1 May 2001

Abstract excerpt

csrRS encodes a two-component regulatory system that represses the transcription of a number of virulence factors in Streptococcus pyogenes, including the hyaluronic acid capsule and pyrogenic exotoxin B. CsrRS-regulated virulence factors have diverse functions during pathogenesis and are differentially expressed throughout growth. This suggests that multiple signals induce CsrRS-mediated gene regulation, or that...

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PMID: 11401704
DOI: 10.1046/j.1365-2958.2001.02441.x

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