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Article

The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway.

Oncogene - 16 May 2002

Gemmill Robert M, Bemis Lynne T, Lee Jason P, Sozen M Ali, Baron Anna, Zeng Chan, Erickson Paul F, Hooper Joan E, Drabkin Harry A

Abstract excerpt

VHL is part of an SCF related E3-ubiquitin ligase complex with 'gatekeeper' function in renal carcinoma. However, no mutations have been identified in VHL interacting proteins in wild type VHL tumors. We previously reported that the TRC8 gene was interrupted by a t(3;8) translocation in a family with hereditary renal and non-medullary thyroid cancer. TRC8 encodes a multi-membrane spanning protein containing a...

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Source

Identifiers

PMID: 12032852
DOI: 10.1038/sj.onc.1205437

Genes

VHL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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