Article
New target genes in endometrial tumors show a role for the estrogen-receptor pathway in microsatellite-unstable cancers.
Human mutation - 1 Dec 2014
Ferreira Ana M, Tuominen Iina, Sousa Sónia, Gerbens Frans, van Dijk-Bos Krista, Osinga Jan, Kooi Krista A, Sanjabi Bahram, Esendam Chris, Oliveira Carla, Terpstra Peter, Hardonk Menno, van der Sluis Tineke, Zazula Monika, Stachura Jerzy, van der Zee Ate G, Hollema Harry, Sijmons Rolf H, Aaltonen Lauri A, Seruca Raquel, Hofstra Robert M W, Westers Helga
Abstract excerpt
Microsatellite instability (MSI) in tumors results in an accumulation of mutations in (target) genes. Previous studies suggest that the profile of target genes differs according to tumor type. This paper describes the first genome-wide search for target genes for mismatch repair-deficient endometrial cancers. Genes expressed in normal endometrium containing coding repeats were analyzed for mutations in tumors. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.