Article
Anti-DNA IgA autoantibodies are spontaneously generated in mouse Peyer's patches.
Immunology - 1 Oct 1998
Shimoda M, Inoue Y, Ametani A, Fujiwara J, Tsuji N M, Kurisaki J, Azuma N, Kanno C
Abstract excerpt
IgA antibodies in the mucosal immune system are produced specifically to environmental antigens such as virus and bacteria, and possibly to some food components, which will provide a potential luminal antigen, DNA. To study the immune response to DNA in the gut, we established B-cell hybridomas p...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Antinuclear
- Antibodies, Monoclonal
- B-Lymphocytes
- Base Sequence
- DNA
- Enzyme-Linked Immunosorbent Assay
- Female
- Hybridomas
- Immunoglobulin A
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation
- Peyer's Patches
- Specific Pathogen-Free Organisms