A comparison of the biological activities of wild-type and mutant p53.

doi:10.1096/fasebj.7.10.8344485

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Article

A comparison of the biological activities of wild-type and mutant p53.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 1993

Zambetti G P, Levine A J

Abstract excerpt

Tumorigenesis is characterized by a series of genetic alterations in both dominant oncogenes and tumor suppressor genes. A hallmark of tumor suppressor genes is that both alleles are generally altered during transformation, which usually represents a loss of function phenotype. The p53 tumor supp...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Transformation, Neoplastic
DNA
Genes, p53
Humans
Molecular Sequence Data
Mutation
Tumor Suppressor Protein p53

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