Article
Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension.
Clinical chemistry - 1 Mar 2006
Sanada Hironobu, Yatabe Junichi, Midorikawa Sanae, Hashimoto Shigeatsu, Watanabe Tsuyoshi, Moore Jason H, Ritchie Marylyn D, Williams Scott M, Pezzullo John C, Sasaki Midori, Eisner Gilbert M, Jose Pedro A, Felder Robin A
Abstract excerpt
BACKGROUND: Salt-sensitive (SS) hypertension affects >30 million Americans and is often associated with low plasma renin activity. We tested the diagnostic validity of several candidate genes for SS and low-renin hypertension. METHODS: In Japanese patients with newly diagnosed, untreated hypertension (n = 184), we studied polymorphisms in 10 genes, including G protein-coupled receptor kinase type 4 (GRK4), some...
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