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Article

Incomplete glycosylation and defective intracellular targeting of mutant solute carrier family 11 member 1 (Slc11a1).

The Biochemical journal - 15 Sept 2004

White Jacqueline K, Stewart Abigail, Popoff Jean-Francois, Wilson Shona, Blackwell Jenefer M

Abstract excerpt

Solute carrier family 11 member 1 (Slc11a1, formerly Nramp1) is a highly glycosylated, 12 transmembrane domain protein expressed in macrophages. It resides in the membrane of late endosomes and lysosomes, where it functions as a bivalent cation transporter. Mice susceptible to infection by various intracellular pathogens including Leishmania donovani and Salmonella typhimurium carry a glycine to aspartic acid...

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Identifiers

PMID: 15202932
DOI: 10.1042/BJ20040808
PMCID: PMC1133956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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