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Article

Identification and functional characterization of novel CYP2J2 variants: G312R variant causes loss of enzyme catalytic activity.

Pharmacogenetics and genomics - 1 Feb 2005

Lee Sang Seop, Jeong Hye-Eun, Liu Kwang-Hyeon, Ryu Ji-Young, Moon Taesung, Yoon Chang No, Oh S June, Yun Chul-Ho, Shin Jae-Gook

Abstract excerpt

CYP2J2 plays important roles in the metabolism of therapeutic drugs, such as astemizole and ebastine, as well as endogenous fatty acids. This study aimed to identify CYP2J2 genetic variants in Koreans and to characterize their functional consequences. From direct sequencing of the CYP2J2 gene, 12 genetic variations, including the two novel nonsynonymous mutations G312R and P351L, were identified from 93 Korean...

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Identifiers

PMID: 15861034
DOI: 10.1097/01213011-200502000-00006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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