Article
Increased drinking in mutant mice with truncated M5 muscarinic receptor genes.
Pharmacology, biochemistry, and behavior - 1 May 2002
Takeuchi Junichi, Fulton James, Jia Zheng-ping, Abramov-Newerly Wanda, Jamot Laure, Sud Manu, Coward David, Ralph Martin, Roder John, Yeomans John
Abstract excerpt
The rarest and least understood of the muscarinic receptors is the M5 subtype. Recombinant methods were used to create mutant mice with a deletion in the third intracellular loop of the M5 receptor gene. Salivation induced by the nonselective muscarinic agonist pilocarpine (1 mg/kg s.c.) was reduced in homozygous mutants from 15 to 60 min after injection as compared with wild-type mice. After 18-h food and water...
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