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Article

1,25-(OH)2-vitamin D3 suppresses the bone-related Runx2/Cbfa1 gene promoter.

Experimental cell research - 1 Apr 2002

Drissi Hicham, Pouliot Arlyssa, Koolloos Christian, Stein Janet L, Lian Jane B, Stein Gary S, van Wijnen André J

Abstract excerpt

The steroid hormone 1,25-(OH)2-vitamin D3 (VD3) regulates osteoblast differentiation by either activating or repressing transcription of numerous bone phenotypic genes. We addressed whether VD3 also influences osteogenesis by controlling activity of the runt-related transcription factor Runx2/Cbfa1, a key regulator of bone formation in vivo. Our data showed that expression of Runx2 was downregulated by VD3 within...

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Source

Identifiers

PMID: 11900492
DOI: 10.1006/excr.2002.5474

Genes

VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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