1,25-(OH)2-vitamin D3 suppresses the bone-related Runx2/Cbfa1 gene promoter.

doi:10.1006/excr.2002.5474

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

1,25-(OH)2-vitamin D3 suppresses the bone-related Runx2/Cbfa1 gene promoter.

Experimental cell research - 1 Apr 2002

Drissi Hicham, Pouliot Arlyssa, Koolloos Christian, Stein Janet L, Lian Jane B, Stein Gary S, van Wijnen André J

Abstract excerpt

The steroid hormone 1,25-(OH)2-vitamin D3 (VD3) regulates osteoblast differentiation by either activating or repressing transcription of numerous bone phenotypic genes. We addressed whether VD3 also influences osteogenesis by controlling activity of the runt-related transcription factor Runx2/Cbfa1, a key regulator of bone formation in vivo. Our data showed that expression of Runx2 was downregulated by VD3 within...

Topics

Animals
Base Sequence
Binding Sites
Bone Development
Calcitriol
Cell Differentiation
Core Binding Factor Alpha 1 Subunit
Dimerization
Down-Regulation
Mutation
Neoplasm Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Osteoblasts

Promoter Regions, Genetic

RNA, Messenger

Rats

Receptors, Calcitriol

Receptors, Retinoic Acid

Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 11900492
DOI: 10.1006/excr.2002.5474

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

1,25-(OH)2-vitamin D3 suppresses the bone-related Runx2/Cbfa1 gene promoter.PMID 11900492Read ↗

Expression and regulation of Runx2/Cbfa1 and osteoblast phenotypic markers during the growth and differentiation of human osteoblasts.Semantic proximity Read ↗

Regulation of gene expression by 1,25-dihydroxyvitamin D3 in bone cells: exploiting new approaches and defining new mechanismsSemantic proximity Read ↗

Enhancers Located within Two Introns of the Vitamin D Receptor Gene Mediate Transcriptional Autoregulation by 1,25-Dihydroxyvitamin D<sub>3</sub>Semantic proximity Read ↗

Genomic Determinants of Gene Regulation by 1,25-Dihydroxyvitamin D3 during Osteoblast-lineage Cell DifferentiationSemantic proximity Read ↗

Characterization of thyroid hormone (T3) receptors in three osteosarcoma cell lines of distinct osteoblast phenotype: interactions among T3, vitamin D3, and retinoid signaling.Semantic proximity Read ↗

1alpha,25-dihydroxy vitamin D(3) induces nuclear matrix association of the 1alpha,25-dihydroxy vitamin D(3) receptor in osteoblasts independently of its ability to bind DNA.Semantic proximity Read ↗

Role and regulation of RUNX2 in osteogenesisSemantic proximity Read ↗

Osteoblast-Specific Transcription Factor Osterix Increases Vitamin D Receptor Gene Expression in OsteoblastsSemantic proximity Read ↗

The Bone-specific Expression of Runx2 Oscillates during the Cell Cycle to Support a G1-related Antiproliferative Function in OsteoblastsSemantic proximity Read ↗

Transcriptional activation of the human osteocalcin gene by basic fibroblast growth factor.Semantic proximity Read ↗

Runx2 Integrates Estrogen Activity in OsteoblastsSemantic proximity Read ↗

Runx2/Cbfa1: A Multifunctional Regulator of Bone FormationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.