Article
Characterization of thyroid hormone (T3) receptors in three osteosarcoma cell lines of distinct osteoblast phenotype: interactions among T3, vitamin D3, and retinoid signaling.
Endocrinology - 1 Dec 1994
Williams G R, Bland R, Sheppard M C
Abstract excerpt
T3 is required for normal skeletal development, but its cellular targets in bone are unknown. T3 regulates target gene transcription via a specific nuclear receptor (T3R), which can heterodimerize with 9-cis-retinoic acid, 1 alpha, 25-dihydroxyvitamin D3, or retinoic acid receptors to modify T3 responsiveness. Serum-free cultures were developed to investigate hormone interactions in three osteosarcoma cell lines,...
Topics
- Animals
- Base Sequence
- Bone Neoplasms
- Cholecalciferol
- Molecular Probes
- Molecular Sequence Data
- Osteoblasts
- Osteosarcoma
- Phenotype
- Rats
- Receptors, Thyroid Hormone