Transcriptional activation of the human osteocalcin gene by basic fibroblast growth factor.

doi:10.1002/jbmr.5650090203

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Article

Transcriptional activation of the human osteocalcin gene by basic fibroblast growth factor.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 1994

Schedlich L J, Flanagan J L, Crofts L A, Gillies S A, Goldberg D, Morrison N A, Eisman J A

Abstract excerpt

Basic fibroblast growth factor (bFGF) has been detected in bone cells and stimulates osteoblast proliferation; however, its role in the regulation of bone metabolism remains speculative. We demonstrated that the human osteocalcin promoter is activated by bFGF when transfected into rat osteoblastic (ROS 17/2.8) cells. This effect is concentration dependent, with a twofold induction at 10 ng/ml detected after 20 h....

Topics

Animals
Base Sequence
Calcitriol
Cell Division
Dose-Response Relationship, Drug
Fibroblast Growth Factor 2
Gene Expression Regulation
Humans
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Osteoblasts

Osteocalcin

Osteosarcoma

Promoter Regions, Genetic

Rats

Regulatory Sequences, Nucleic Acid

Sequence Deletion

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 8140927
DOI: 10.1002/jbmr.5650090203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8140927-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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