1alpha,25-dihydroxy vitamin D(3) induces nuclear matrix association of the 1alpha,25-dihydroxy vitamin D(3) receptor in osteoblasts independently of its ability to bind DNA.

doi:10.1002/jcp.21958

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Article

1alpha,25-dihydroxy vitamin D(3) induces nuclear matrix association of the 1alpha,25-dihydroxy vitamin D(3) receptor in osteoblasts independently of its ability to bind DNA.

Journal of cellular physiology - 1 Feb 2010

Arriagada Gloria, Paredes Roberto, van Wijnen Andre J, Lian Jane B, van Zundert Brigitte, Stein Gary S, Stein Janet L, Montecino Martin

Abstract excerpt

1alpha,25-dihydroxy vitamin D(3) (vitamin D(3)) has an important role during osteoblast differentiation as it directly modulates the expression of key bone-related genes. Vitamin D(3) binds to the vitamin D(3) receptor (VDR), a member of the superfamily of nuclear receptors, which in turn interacts with transcriptional activators to target this regulatory complex to specific sequence elements within gene...

Topics

Animals
Binding Sites
Calcitriol
Cell Line, Tumor
Core Binding Factor Alpha 1 Subunit
DNA
Humans
Ligands
Mediator Complex Subunit 1
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nuclear Matrix

Osteoblasts

Protein Binding

Protein Structure, Tertiary

Rats

Receptors, Calcitriol

Recombinant Fusion Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19885846
DOI: 10.1002/jcp.21958
PMCID: PMC3106996

Genes

VDR
MED1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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