Article
Ion channelopathy and hyperphosphorylation contributing to cardiac arrhythmias.
Acta pharmacologica Sinica - 1 Aug 2005
Dai De-zai, Yu Feng
Abstract excerpt
The occurrence of cardiac arrhythmias is related to the abnormality of ion channels not only in sarcolemma but also in the sarcoplasmic reticulum, which regulates the process of calcium release and up-take intracellularly. Patterns of ion channelopathy in the sarcolemma can be divided into single channel disorder from gene mutations and multiple channels disorder in a diseased hypertrophied heart. Abnormal RyR2,...
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