Molecular Basis for G2 Arrest Induced by 2′- C -Cyano-2′-Deoxy-1-β- d - Arabino -Pentofuranosylcytosine and Consequences of Checkpoint Abrogation

doi:10.1158/0008-5472.can-05-0288

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Article

Molecular Basis for G2 Arrest Induced by 2′- C -Cyano-2′-Deoxy-1-β- d - Arabino -Pentofuranosylcytosine and Consequences of Checkpoint Abrogation

1 Aug 2005

Abstract excerpt

2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine (CNDAC) is a nucleoside analogue with a novel mechanism of action that is currently being evaluated in clinical trials. Incorporation of CNDAC triphosphate into DNA and extension during replication leads to single-strand breaks directly caused by beta-elimination. These breaks, or the lesions that arise from further processing, cause cells to arrest in...

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PMID: 16061671
DOI: 10.1158/0008-5472.can-05-0288

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