Article
Checkpoint kinase 2 is dispensable for regulation of the p53 response but is required for G2/M arrest and cell survival in cells with p53 defects under heat stress.
Apoptosis : an international journal on programmed cell death - 1 Oct 2017
Furusawa Yukihiro, Yamanouchi Yuka, Iizumi Takashi, Zhao Qing-Li, Mitsuhashi Yohei, Morita Akinori, Enomoto Atushi, Tabuchi Yoshiaki, Kondo Takashi
Abstract excerpt
Hyperthermia induced by heat stress (HS) is known to inhibit proliferation and induce cell death in cancer. We previously demonstrated that checkpoint kinase 1 (Chk1) contributes to G2/M arrest and cell survival under HS; however, the role of Chk2, a functional analog of Chk1, in regulation of the cell cycle and cell death under HS is still unknown. Here, we addressed the role of Chk2 using Molt-4 cells with...
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