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Tailoring the Host Range of Ackermannviridae Bacteriophages through Chimeric Tailspike Proteins

19 Jan 2023

Abstract excerpt

Host range is a major determinant in the industrial utility of a bacteriophage. A model host range permits broad recognition across serovars of a target bacterium while avoiding cross-reactivity with commensal microbiota. Searching for a naturally occurring bacteriophage with ideal host ranges is challenging, time-consuming, and restrictive. To address this, SPTD1.NL, a previously published luciferase reporter...

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PMID: 36851500
DOI: 10.3390/v15020286

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