Article
Contributions of the LG modules and furin processing to laminin-2 functions.
The Journal of biological chemistry - 24 May 2002
Smirnov Sergei P, McDearmon Erin L, Li Shaohua, Ervasti James M, Tryggvason Karl, Yurchenco Peter D
Abstract excerpt
The alpha2-laminin subunit contributes to basement membrane functions in muscle, nerve, and other tissues, and mutations in its gene are causes of congenital muscular dystrophy. The alpha2 G-domain modules, mutated in several of these disorders, are thought to mediate different cellular interactions. To analyze these contributions, we expressed recombinant laminin-2 (alpha(2)beta(1)gamma(1)) with LG4-5, LG1-3,...
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