Article
Different effects of high and low shear stress on platelet-derived growth factor isoform release by endothelial cells: consequences for smooth muscle cell migration.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2002
Palumbo Roberta, Gaetano Carlo, Antonini Annalisa, Pompilio Giulio, Bracco Enrico, Rönnstrand Lars, Heldin Carl-Henrik, Capogrossi Maurizio C
Abstract excerpt
In the present study, we analyzed the effect of conditioned media (CM) from bovine aortic endothelial cells exposed to laminar shear stress (SS) of 5 dyne/cm2 (SS5) or 15 dyne/cm2 (SS15) for 16 hours on smooth muscle cell (SMC) migration. In response to CM from bovine aortic endothelial cells exposed to SS5 (CMSS5) and SS15 (CMSS15), migration was 45 +/- 5.5 and 30 +/- 1.5 cells per field, respectively (P<0.05)....
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