Article
[Construction of membrane-anchored interleukin-6 receptor beta subunit mutant and its effect on IL-6 signal transduction].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 Dec 2000
Yang Z, Ni C, Shen B, Wang J, Wang Z
Abstract excerpt
OBJECTIVE: To investigate whether the membrane-anchored gp130 mutant containing the second and the third fibronectin type III modules of the extracellular region could still transduce IL-6 signal. METHOD: The membrane-anchored gp130 mutant cDNA was amplified by the overlap extension PCR and inserted into the mammalian expression vector pRc/RSV. The mutant was proved to be effectively expressed in SKO-007 cells...
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