Article
Influence of HLA polymorphism on persistent remission in rheumatoid arthritis.
Annals of the rheumatic diseases - 1 Apr 2002
Molenaar E T H, Voskuyl A E, van der Horst-Bruinsma I E, Schreuder G M Th, Zanelli E, Dijkmans B A C
Abstract excerpt
BACKGROUND: Several studies have reported an association between the presence of the shared epitope (SE) and susceptibility to rheumatoid arthritis (RA). Recent studies have shown that certain HLA-DRB1 alleles in combination with predisposing DQB1 and DQA1 alleles may protect against the development of RA. This model is known as the rheumatoid arthritis protection (RAP) hypothesis. OBJECTIVE: To determine the...
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