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Article

HLA association with autoimmune disease: a failure to protect?

Rheumatology (Oxford, England) - 1 Oct 2000

Zanelli E, Breedveld F C, de Vries R R

Abstract excerpt

That certain HLA specificities are associated with predisposition to autoimmune disease does not necessarily imply that self-reactive T cells restricted to particular HLA alleles are eliciting the disease. In the present essay, we argue that HLA can be a major genetic factor in the development of autoimmune diseases without T cells being primarily involved in its initiation or perpetuation. There is now ample...

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Identifiers

PMID: 11035123
DOI: 10.1093/rheumatology/39.10.1060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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