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Article

CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains.

Nature - 24 Feb 2005

Vergani Paola, Lockless Steve W, Nairn Angus C, Gadsby David C

Abstract excerpt

ABC (ATP-binding cassette) proteins constitute a large family of membrane proteins that actively transport a broad range of substrates. Cystic fibrosis transmembrane conductance regulator (CFTR), the protein dysfunctional in cystic fibrosis, is unique among ABC proteins in that its transmembrane domains comprise an ion channel. Opening and closing of the pore have been linked to ATP binding and hydrolysis at...

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Identifiers

PMID: 15729345
DOI: 10.1038/nature03313
PMCID: PMC2756053

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains.PMID 15729345Read ↗

Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerizationSemantic proximity Read ↗

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Estimating the true stability of the prehydrolytic outward-facing state in an ABC proteinSemantic proximity Read ↗

Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein.Semantic proximity Read ↗

CFTR function, pathology and pharmacology at single-molecule resolutionSemantic proximity Read ↗

Mutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gating.Semantic proximity Read ↗

Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.Semantic proximity Read ↗

Electrophysiological, biochemical, and bioinformatic methods for studying CFTR channel gating and its regulation.Semantic proximity Read ↗

The most common cystic fibrosis‐associated mutation destabilizes the dimeric state of the nucleotide‐binding domains of CFTRSemantic proximity Read ↗

A stable ATP binding to the nucleotide binding domain is important for reliable gating cycle in an ABC transporter CFTR.Semantic proximity Read ↗

A Topological Switch in the Cystic Fibrosis Transmembrane Conductance Regulator Modulates Channel Activity and Sensitivity to Disease-Causing MutationSemantic proximity Read ↗

Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2.Semantic proximity Read ↗

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