Article
Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
The EMBO journal - 28 Jan 2004
Lewis Hal A, Buchanan Sean G, Burley Stephen K, Conners Kris, Dickey Mark, Dorwart Michael, Fowler Richard, Gao Xia, Guggino William B, Hendrickson Wayne A, Hunt John F, Kearins Margaret C, Lorimer Don, Maloney Peter C, Post Kai W, Rajashankar Kanagalaghatta R, Rutter Marc E, Sauder J Michael, Shriver Stephanie, Thibodeau Patrick H, Thomas Philip J, Zhang Marie, Zhao Xun, Emtage Spencer
Abstract excerpt
Cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-binding cassette (ABC) transporter that functions as a chloride channel. Nucleotide-binding domain 1 (NBD1), one of two ABC domains in CFTR, also contains sites for the predominant CF-causing mutation and, potentially, for regulatory phosphorylation. We have determined crystal structures for mouse NBD1 in unliganded, ADP- and ATP-bound states,...
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