Article
Molecular mechanisms of early lung specification and branching morphogenesis.
Pediatric research - 1 May 2005
Warburton David, Bellusci Saverio, De Langhe Stijn, Del Moral Pierre-Marie, Fleury Vincent, Mailleux Arnaud, Tefft Denise, Unbekandt Mathieu, Wang Kasper, Shi Wei
Abstract excerpt
The "hard wiring" encoded within the genome that determines the emergence of the laryngotracheal groove and subsequently early lung branching morphogenesis is mediated by finely regulated, interactive growth factor signaling mechanisms that determine the automaticity of branching, interbranch length, stereotypy of branching, left-right asymmetry, and finally gas diffusion surface area. The extracellular matrix is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.