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Article

Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice.

Oncogene - 24 Jun 2004

Oh Junseo, Takahashi Rei, Adachi Eijiro, Kondo Shunya, Kuratomi Shinobu, Noma Akinori, Alexander David B, Motoda Hirotoshi, Okada Akiko, Seiki Motoharu, Itoh Takeshi, Itohara Shigeyoshi, Takahashi Chiaki, Noda Makoto

Abstract excerpt

The matrix metalloproteinase (MMP) family (approximately 25 members in mammals) has been implicated in extracellular matrix remodeling associated with embryonic development, cancer formation and progression, and various other physiological and pathological events. Inactivating mutations in individual matrix metalloproteinase genes in mice described so far, however, are nonlethal at least up to the first few weeks...

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PMID: 15064723
DOI: 10.1038/sj.onc.1207688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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