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Expression analysis of the entire MMP and TIMP gene families during mouse tissue development

19 Mar 2004

Abstract excerpt

Matrix metalloproteinases (MMPs) and adamalysins (ADAMs) cleave many extracellular proteins, including matrix, growth factors, and receptors. We profiled the RNA levels of every MMP, several ADAMs, and inhibitors of metalloproteinases (TIMPs and RECK) in numerous mouse tissues during development and in the uterus during pregnancy. Observations include: most secreted MMPs are expressed at low to undetectable...

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PMID: 15063736
DOI: 10.1016/s0014-5793(04)00281-9

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