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Article

The BEACH is hot: a LYST of emerging roles for BEACH-domain containing proteins in human disease.

Traffic (Copenhagen, Denmark) - 1 Jul 2013

Cullinane Andrew R, Schäffer Alejandro A, Huizing Marjan

Abstract excerpt

BEACH (named after 'Beige and Chediak-Higashi') is a conserved ∼280 residue domain, present in nine human BEACH domain containing proteins (BDCPs). Most BDCPs are large, containing a PH-like domain for membrane association preceding their BEACH domain, and containing WD40 and other domains for ligand binding. Recent studies found that mutations in individual BDCPs cause several human diseases. BDCP alterations...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Adaptor Proteins, Vesicular Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amino Acid Sequence

Share to Disease

Share to Lysosomes

Share to Membrane Proteins

Share to Molecular Sequence Data

Share to Protein Structure, Tertiary

Source

Open in PubMed Open full text

Identifiers

PMID: 23521701
DOI: 10.1111/tra.12069
PMCID: PMC3761935

Genes

LYST
NBEA
NSMAF
LRBA
NBEAL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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