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Article

Binding to Elongin C inhibits degradation of interacting proteins in yeast.

The Journal of biological chemistry - 3 May 2002

Hyman Linda E, Kwon Edward, Ghosh Sumana, McGee Jennifer, Chachulska Anna M Boguszewska, Jackson Tanya, Baricos William H

Abstract excerpt

Elongin C is a highly conserved, low molecular weight protein found in a variety of multiprotein complexes in human, rat, fly, worm, and yeast cells. Among the best characterized of these complexes is a mammalian E3 ligase that targets proteins for ubiquitination and subsequent degradation by the 26 S proteasome. Despite its crucial role as a component of such E3 ligases and other complexes, the specific function...

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PMID: 11864988
DOI: 10.1074/jbc.M200800200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Binding to Elongin C inhibits degradation of interacting proteins in yeast.PMID 11864988Read ↗

RNA polymerase II elongator holoenzyme is composed of two discrete subcomplexes.Semantic proximity Read ↗

ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells.Semantic proximity Read ↗

Saccharomyces cerevisiae Ub-conjugating enzyme Ubc4 binds the proteasome in the presence of translationally damaged proteins.Semantic proximity Read ↗

Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

Dimerization of elongator protein 1 is essential for Elongator complex assembly.Semantic proximity Read ↗

Requirement of ELC1 for RNA polymerase II polyubiquitylation and degradation in response to DNA damage in Saccharomyces cerevisiae.Semantic proximity Read ↗

Identification of Elongin C and Skp1 sequences that determine Cullin selection.Semantic proximity Read ↗

The RNA binding protein ELF9 directly reduces SUPPRESSOR OF OVEREXPRESSION OF CO1 transcript levels in arabidopsis, possibly via nonsense-mediated mRNA decay.Semantic proximity Read ↗

Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger-dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.Semantic proximity Read ↗

Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation.Semantic proximity Read ↗

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