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Article

Activin A Augments GnRH-Mediated Transcriptional Activation of the Mouse GnRH Receptor Gene

1 Mar 2002

Abstract excerpt

The response of pituitary gonadotropes to GnRH correlates directly with the concentration of GnRH receptors (GnRHRs) on the cell surface, which is mediated in part at the level of GnRHR gene expression. We have previously localized GnRH responsiveness in the mouse GnRHR (mGnRHR) gene promoter to two elements: activating protein-1 and sequence underlying responsiveness to GnRH-1. This study was designed to...

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Identifiers

PMID: 11861523
DOI: 10.1210/endo.143.3.8663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activin A Augments GnRH-Mediated Transcriptional Activation of the Mouse GnRH Receptor GenePMID 11861523Read ↗

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Oct-1 and nuclear factor Y bind to the SURG-1 element to direct basal and gonadotropin-releasing hormone (GnRH)-stimulated mouse GnRH receptor gene transcription.Semantic proximity Read ↗

Homologous Regulation of the Gonadotropin-Releasing Hormone Receptor Gene Is Partially Mediated by Protein Kinase C Activation of an Activator Protein-1 ElementSemantic proximity Read ↗

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Activator Protein-1 and Smad Proteins Synergistically Regulate Human Follicle-Stimulating Hormone β-Promoter ActivitySemantic proximity Read ↗

Molecular mechanisms of gonadotropin-releasing hormone receptor gene regulation.Semantic proximity Read ↗

Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1.Semantic proximity Read ↗

Distal Enhancer Potentiates Activin- and GnRH-Induced Transcription of FSHBSemantic proximity Read ↗

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Steroidogenic Factor-1 Interacts with a Gonadotrope-Specific Element within the First Exon of the Human Gonadotropin-Releasing Hormone Receptor Gene to Mediate Gonadotrope-Specific Expression*Semantic proximity Read ↗

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