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Article

Synergy between activin A and gonadotropin-releasing hormone in transcriptional activation of the rat follicle-stimulating hormone-beta gene.

Molecular endocrinology (Baltimore, Md.) - 1 Jan 2005

Gregory Susan J, Lacza Charlemagne T, Detz Alissa A, Xu Shuyun, Petrillo Laura A, Kaiser Ursula B

Abstract excerpt

Both activin and GnRH can independently stimulate expression of the FSHbeta subunit gene. In this study, we used the gonadotrope-derived LbetaT2 cell line to investigate the potential interaction between activin and GnRH in regulating the transcriptional activity of the rat FSHbeta gene promoter....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15375186
DOI: 10.1210/me.2003-0473

Genes

SMAD3
SMAD2
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15375186-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synergy between activin A and gonadotropin-releasing hormone in transcriptional activation of the rat follicle-stimulating hormone-beta gene.PMID 15375186Read ↗

Synergistic induction of follicle-stimulating hormone beta-subunit gene expression by gonadal steroid hormone receptors and Smad proteins.Semantic proximity Read ↗

FOXL2 Is Involved in the Synergy between Activin and Progestins on the Follicle-Stimulating Hormone β-Subunit PromoterSemantic proximity Read ↗

Activator Protein-1 and Smad Proteins Synergistically Regulate Human Follicle-Stimulating Hormone β-Promoter ActivitySemantic proximity Read ↗

Activin A Augments GnRH-Mediated Transcriptional Activation of the Mouse GnRH Receptor GeneSemantic proximity Read ↗

Distal Enhancer Potentiates Activin- and GnRH-Induced Transcription of FSHBSemantic proximity Read ↗

Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1.Semantic proximity Read ↗

Pituitary homeobox 1 activates the rat FSHbeta (rFSHbeta) gene through both direct and indirect interactions with the rFSHbeta gene promoter.Semantic proximity Read ↗

A Novel Role for the Forkhead Transcription Factor FOXL2 in Activin A-Regulated Follicle-Stimulating Hormone β Subunit TranscriptionSemantic proximity Read ↗

Activation of Luteinizing Hormone β Gene by Gonadotropin-releasing Hormone Requires the Synergy of Early Growth Response-1 and Steroidogenic Factor-1Semantic proximity Read ↗

Activin B can signal through both ALK4 and ALK7 in gonadotrope cellsSemantic proximity Read ↗

Small nuclear RING finger protein stimulates the rat luteinizing hormone-beta promoter by interacting with Sp1 and steroidogenic factor-1 and protects from androgen suppression.Semantic proximity Read ↗

Roles of activin and its signal transduction mechanisms in reproductive tissuesSemantic proximity Read ↗

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