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Article

Synergy between activin A and gonadotropin-releasing hormone in transcriptional activation of the rat follicle-stimulating hormone-beta gene.

Molecular endocrinology (Baltimore, Md.) - 1 Jan 2005

Gregory Susan J, Lacza Charlemagne T, Detz Alissa A, Xu Shuyun, Petrillo Laura A, Kaiser Ursula B

Abstract excerpt

Both activin and GnRH can independently stimulate expression of the FSHbeta subunit gene. In this study, we used the gonadotrope-derived LbetaT2 cell line to investigate the potential interaction between activin and GnRH in regulating the transcriptional activity of the rat FSHbeta gene promoter. Activin A and GnRH synergistically enhanced rat FSHbeta transcriptional activity. Overexpression of SMAD3 (mediator of...

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Source

Identifiers

PMID: 15375186
DOI: 10.1210/me.2003-0473

Genes

SMAD3
SMAD2
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Synergy between activin A and gonadotropin-releasing hormone in transcriptional activation of the rat follicle-stimulating hormone-beta gene.PMID 15375186Read ↗

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