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Article

Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to gamma-radiation and premature senescence.

Cancer research - 1 Aug 1998

Morimatsu M, Donoho G, Hasty P

Abstract excerpt

The putative Brca2-MmRad51 interaction is analyzed in mouse cells deleted for the COOH terminus of Brca2 (amino acids 3140-3328), which contains a region that associates with MmRad51 by yeast two-hybrid. These cells are hypersensitive to gamma-radiation (suggesting defective recombinational repai...

Topics

Animals
BRCA2 Protein
Cell Division
Cellular Senescence
DNA Damage
DNA Repair
DNA-Binding Proteins
Exons
Fibroblasts
Gamma Rays
Gene Deletion
Gene Targeting
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplasm Proteins

Radiation Tolerance

Transcription Factors

Source

Identifiers

PMID: 9699678

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9699678-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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