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Article

Characterization of a Novel SOD-1(G93A) Transgenic Mouse Line with Very Decelerated Disease Development

11 Nov 2010

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a fatal motoneuron disease, characterized by progressive weakness, muscle wasting and death ensuing 3-5 years after diagnosis. The etiology of ALS is complex and therapeutic approaches rely mostly on transgenic animal models with SOD-1 mutations. Most frequently employed is a mouse line transgenic for SOD-1 (SOD-1 Tg) that contains a point mutation at amino acid position 93...

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PMID: 21102999
DOI: 10.1371/journal.pone.0015445

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