Article
Altered expression of integrins and basement membrane proteins in malignant and pre-malignant lesions of oral mucosa.
Journal of biological regulators and homeostatic agents - 1 Jan 2000
Giannelli G, Milillo L, Marinosci F, Lo Muzio L, Serpico R, Antonaci S
Abstract excerpt
Integrins are transmembrane receptors that regulate cell-cell and cell-extracellular matrix (ECM) contact. In epithelial tissues, they interact with ECM components of the basement membrane (BM) to maintain the homeostasis and the architecture of the tissue. This interaction controls several cell functions such as adhesion, migration, proliferation, differentiation, and therefore has a key role in cancer...
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