Article
Metastatic growth of squamous cell carcinomas is correlated with upregulation and redistribution of hemidesmosomal components.
Cell and tissue research - 1 Dec 2001
Herold-Mende C, Kartenbeck J, Tomakidi P, Bosch F X
Abstract excerpt
Bullous pemphigoid antigen-1 (BPA1) and alpha(6)beta(4)-integrin colocalize at the hemidesmosomes in basal-layer keratinocytes of normal squamous epithelia. The expression of these genes was analyzed during the process of tumor cell invasion and metastasis on frozen sections of head and neck biopsies, and the structural appearance of hemidesmosomes was analyzed by electron microscopy. Despite a diminution of...
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