Article
The factor VIII/von Willebrand factor ratio discriminates between reduced synthesis and increased clearance of von Willebrand factor.
Thrombosis and haemostasis - 1 Feb 2002
Eikenboom Jeroen C J, Castaman Giancarlo, Kamphuisen Pieter W, Rosendaal Frits R, Bertina Rogier M
Abstract excerpt
It is often stated that a decrease in Von Willebrand factor (VWF), the carrier protein of factor VIII, results in a concordant change in factor VIII. Clinical data suggest that this is not always the case and we hypothesized that the ratio between factor VIII and VWF depends on the genetic defect that causes the VWF deficiency. We have analyzed the ratio between plasma factor VIII and VWF in several subtypes of...
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