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Article

VWF propeptide and ratios between VWF, VWF propeptide, and FVIII in the characterization of type 1 von Willebrand disease.

Blood - 21 Mar 2013

Eikenboom Jeroen, Federici Augusto B, Dirven Richard J, Castaman Giancarlo, Rodeghiero Francesco, Budde Ulrich, Schneppenheim Reinhard, Batlle Javier, Canciani Maria Teresa, Goudemand Jenny, Peake Ian, Goodeve Anne

Abstract excerpt

During posttranslational modifications of von Willebrand factor (VWF), the VWF propeptide (VWFpp) is cleaved. The ratio between VWFpp and VWF antigen (VWF:Ag) and the ratio between factor VIII (FVIII:C) and VWF:Ag may be used to assess synthesis and clearance of VWF. We analyzed the contribution of VWFpp and ratios of VWFpp/VWF:Ag and FVIII:C/VWF:Ag in the pathophysiological characterization of type 1 von...

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Identifiers

PMID: 23349392
DOI: 10.1182/blood-2012-09-455089
PMCID: PMC4191434

Genes

VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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