Article
von Willebrand factor propeptide and the phenotypic classification of von Willebrand disease.
Blood - 7 May 2015
Sanders Yvonne V, Groeneveld Dafna, Meijer Karina, Fijnvandraat Karin, Cnossen Marjon H, van der Bom Johanna G, Coppens M, de Meris Joke, Laros-van Gorkom Britta A P, Mauser-Bunschoten Eveline P, Leebeek Frank W G, Eikenboom Jeroen
Abstract excerpt
The ratios between von Willebrand factor propeptide (VWFpp) or factor VIII activity ( FVIII: C) and VWF antigen (VWF:Ag) reflect synthesis, secretion, and clearance of VWF. We aimed to define the pathophysiology of 658 patients with type 1, 2, or 3 von Willebrand disease (VWD) with VWF levels ≤30 U/dL from the Willebrand in The Netherlands (WiN) study using the VWFpp/VWF:Ag and FVIII: C/VWF:Ag ratios. We...
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