Article
The genetic defect of type I von Willebrand disease "Vicenza" is linked to the von Willebrand factor gene.
Thrombosis and haemostasis - 1 Feb 1993
Randi A M, Sacchi E, Castaman G C, Rodeghiero F, Mannucci P M
Abstract excerpt
Type I von Willebrand disease (vWD) Vicenza is a rare variant with autosomal dominant transmission, characterized by the presence of supranormal von Willebrand factor (vWF) multimers in plasma, similar to those normally found in endothelial cells and megakaryocytes. The patients have very low levels of plasma vWF contrasting with a mild bleeding tendency. The pathophysiology of this subtype is still unknown. The...
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