Article
von Willebrand factor: evidence for variable clearance in vivo according to Y/C1584 phenotype and ABO blood group.
Journal of thrombosis and haemostasis : JTH - 1 Jan 2008
Davies J A, Collins P W, Hathaway L S, Bowen D J
Abstract excerpt
BACKGROUND: The plasma von Willebrand factor (VWF) level (VWF:Ag) is known to correlate with the VWF Y/C1584 variation and with ABO blood group. The ratio of the VWF propeptide (VWFpp) to VWF:Ag and the ratio of coagulation factor VIII (FVIII:C) to VWF:Ag have previously been used as indicators of VWF clearance and/or secretion. OBJECTIVES AND METHODS: To investigate the mechanism underlying the relationship...
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