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Article

Angiostatin gene transfer: Inhibition of tumor growth <i>in vivo</i> by blockage of endothelial cell proliferation associated with a mitosis arrest

26 May 1998

Abstract excerpt

The antitumoral effects that follow the local delivery of the N-terminal fragment of human plasminogen (angiostatin K3) have been studied in two xenograft murine models. Angiostatin delivery was achieved by a defective adenovirus expressing a secretable angiostatin K3 molecule from the cytomegalovirus promoter (AdK3). In in vitro studies, AdK3 selectively inhibited endothelial cell proliferation and disrupted the...

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PMID: 9600971
DOI: 10.1073/pnas.95.11.6367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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