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Article

Identification of key residues involved in mediating the in vivo anti-tumor/anti-endothelial activity of Alphastatin.

Journal of thrombosis and haemostasis : JTH - 1 Apr 2007

Staton C A, Stribbling S M, García-Echeverría C, Bury J P, Tazzyman S, Lewis C E, Brown N J

Abstract excerpt

BACKGROUND: We have recently shown that Alphastatin, a 24-amino-acid peptide (ADSGEGDFLAEGGGVRGPRVVERH) derived from human fibrinogen has anti-endothelial properties in vitro and in vivo. OBJECTIVES: The aim of this study was to determine the activity of a terminally modified (stabilized) form of Alphastatin in vitro and in vivo and to identify the key residues required for this activity. METHODS: The in vitro...

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Source

Identifiers

PMID: 17408413
DOI: 10.1111/j.1538-7836.2007.02432.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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