Article
Activation of NF-kappaB is required for PDGF-B chain to transform NIH3T3 cells.
Experimental cell research - 10 Mar 2002
Shimamura Takeshi, Hsu Tin-Chen, Colburn Nancy H, Bejcek Bruce E
Abstract excerpt
Elucidating the secondary signaling molecules that are necessary for platelet-derived growth factor (PDGF) to stimulate tumor development will be crucial to the understanding and treatment of a variety of cancers. Several lines of evidence have indicated that the transcription factor NF-kappaB plays a central role in transformation induced by Ha-ras and Bcr-abl, but nothing is known concerning its role in...
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