Article
A novel allelic variant of the human TSG-6 gene encoding an amino acid difference in the CUB module. Chromosomal localization, frequency analysis, modeling, and expression.
The Journal of biological chemistry - 3 May 2002
Nentwich Hilke A, Mustafa Zehra, Rugg Marilyn S, Marsden Brian D, Cordell Martin R, Mahoney David J, Jenkins Suzanne C, Dowling Barbara, Fries Erik, Milner Caroline M, Loughlin John, Day Anthony J
Abstract excerpt
Tumor necrosis factor-stimulated gene-6 (TSG-6) encodes a 35-kDa protein, which is comprised of contiguous Link and CUB modules. TSG-6 protein has been detected in the articular joints of osteoarthritis (OA) patients, with little or no constitutive expression in normal adult tissues. It interacts with components of cartilage matrix (e.g. hyaluronan and aggrecan) and thus may be involved in extracellular...
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