Article

The recombinant Link module of human TSG-6 suppresses cartilage damage in models of osteoarthritis: a potential disease-modifying OA drug

2021-03-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> To investigate the role of endogenous TSG-6 in human osteoarthritis (OA) and assess the disease-modifying potential of a TSG-6-based biological treatment in cell, explant and animal models of OA. <h4>Methods</h4> Knee articular cartilages from OA patients were analysed for TSG-6 protein and mRNA expression using immunohistochemistry and RNAscope, respectively. The inhibitory a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 71e8a545-ca10-5b83-9fca-b268ebffa224
DOI: 10.1101/2021.03.23.21254102

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The recombinant Link module of human TSG-6 suppresses cartilage damage in models of osteoarthritis: a potential disease-modifying OA drugDOI 10.1101/2021.03.23.21254102Read

Abnormal expression of TSG-6 disturbs extracellular matrix homeostasis in chondrocytes from endemic osteoarthritisSemantic proximity Read

Recent advances in the treatment of osteoarthritisSemantic proximity Read

The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions.Semantic proximity Read

Homeostasis of the intervertebral disc requires regulation of STAT3 signaling by the adhesion G-protein coupled receptor ADGRG6Semantic proximity Read

Interleukin-6 Signaling Mediates Cartilage Degradation and Pain in Post-Traumatic OsteoarthritisSemantic proximity Read

A novel allelic variant of the human TSG-6 gene encoding an amino acid difference in the CUB module. Chromosomal localization, frequency analysis, modeling, and expression.Semantic proximity Read

Matrikine stimulation of equine synovial fibroblasts and chondrocytes results in an in vitro osteoarthritis phenotype.Semantic proximity Read

Network-based cytokine inference implicates Oncostatin M as a driver of an inflammation phenotype in knee osteoarthritis.Semantic proximity Read

Prg4 and Osteoarthritis: Functions, Regulatory Factors, and Treatment StrategiesSemantic proximity Read

Multi-Target Gene Therapy for Osteoarthritis: Dual-Axis Modeling and In Silico ValidationSemantic proximity Read

Systemic Transplantation of Adult Multipotent Stem Cells Prevents Articular Cartilage Degeneration in a Mouse Model of Accelerated AgeingSemantic proximity Read

A Stem Cell–Based Approach to Cartilage RepairSemantic proximity Read